KANSAS CITY, Mo. (AP) -- Ryan Fitzpatrick threw four touchdown passes, two of them to journeyman tight end Scott Chandler, and the Buffalo Bills romped to a season-opening 41-7 victory over the Kansas City Chiefs on Sunday.
Fitzpatrick finished with 208 yards passing for the Bills, who who hadn't score 40 points in an opener since a 40-7 victory over the Los Angeles Rams on Sept. 6, 1992.
Fred Jackson added 112 yards rushing for Buffalo.
Matt Cassel threw for 119 yards with a touchdown and interception for Kansas City.
It was the most lopsided season-opening loss in franchise history, and the worst home loss by the Chiefs since a 45-0 loss to the Pittsburgh Steelers 35 years ago.