The host Chinooks took control early, limiting the Wildcats to 12 first-half points in the 1A Trico League game.
Kalama (4-0) led 24-6 after one quarter, and the margin was 38 points by the end of three quarters.
Connor Wonderly scored 17 to provide almost half of the points for La Center (3-3, 2-2).
Jared Nieman scored 16 points for Kalama, topping three Chinooks who scored in double figures.
KALAMA 65, LA CENTER 36
LA CENTER — Wyatt Aguirre 2, Dylan King 2, Connor Wonderly 17, Matt Braaten, Jamison Benitez 4, Jonathan Griffee 4, Jeremiah Arn 1, Levi Van Tol 4, Max Hiller 2. Totals 14 (2) 6-12 36.