CHICAGO (AP) -- Anna Martin scored 19 points and Katherine Harry had a career-high 20 rebounds and six assists, leading DePaul to an 86-61 rout of No. 14 Louisville on Tuesday night.
The win was the second straight for the Blue Demons (17-6, 5-4 Big East) while the Cardinals (17-5, 6-3) had their three-game winning streak snapped.
Brittany Hrynko scored 18 points, Jasmine Penny and Harry had 14 points, and Megan Rogowski added 11 for DePaul, which never trailed.
Shoni Schimmel had 14 points and Asia Taylor added 12 points and 10 rebounds for Louisville.
Five different players scored early -- including eight points from Martin -- as DePaul burst to a 17-2 lead through the opening 6:26.
DePaul, limited by injuries to a seven-player rotation, opened its biggest lead at 77-47 on Deanna Ortiz' 3 pointer with 5:40 to play.
DePaul improved to 10-1 at home, the only loss coming against No. 3 Connecticut.