Harbaugh praises 49ers for response to adversity

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SANTA CLARA, Calif. (AP) -- The San Francisco 49ers turned a short week of negative energy into their first blowout victory of the season.

The 49ers responded to a two-game losing streak and the loss of four key defensive players by dominating the St. Louis Rams 35-11 Thursday night.

Coach Jim Harbaugh on Friday praised the way his 2-2 team responded against the Rams and to the adversity and criticism it faced during a tumultuous stretch that included lopsided losses against Seattle and Indianapolis -- San Francisco's first back-to-back defeats since he took over as coach in 2011.

Though the 49ers added to their long injury list in St. Louis, they now have 10 days to get healthy before they host the Houston Texans in the Sunday night spotlight Oct. 6.