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Opioid addiction treatments face off in first such U.S. trial

Monthly shot can work for those willing to detox first

By CARLA K. JOHNSON, Associated Press
Published: November 14, 2017, 5:51pm

CHICAGO — The first U.S. study to compare two treatments for opioid addiction finds a monthly shot works as well as a daily drug to prevent relapse.

The shot requires days of detox first and that proved to be a stumbling block for many. For those who made it past that hurdle, the shot Vivitrol worked about the same as an older treatment, Suboxone.

Both drugs had high relapse rates and there were overdoses, including fatal ones, in the experiment in 570 adults. The study, published Tuesday in the journal Lancet, is the first to compare the two drugs in the United States, where an opioid addiction epidemic has doctors and policymakers deeply divided over treatment strategies.

Many addiction treatment programs don’t offer either medication, or only one of them.

“Let’s not keep arguing about the exact batting averages of these two things,” and make them more available, said study co-author Dr. Joshua Lee of New York University School of Medicine.

President Donald Trump recently declared the crisis a national public health emergency. Overdoses, most involving prescription painkillers and other opioids, killed 64,000 people in the United States last year.

A smaller Norwegian study, published last month, also found the two medications work equally well.

The new study recruited users of heroin and pain pills from eight detox centers across the United States. Half were assigned to get monthly shots of Vivitrol, which contains extended-release naltrexone. The others got daily Suboxone, a buprenorphine-naloxone combo in a film that dissolves under the tongue.

After six months of outpatient treatment, including voluntary counseling, 65 percent of the Vivitrol group had relapsed compared to 57 percent of the Suboxone group. Anyone who dropped out of the study was scored as having relapsed.

The difference in the groups stemmed almost entirely from patients who left during detox for Vivitrol. Twenty-eight percent dropped out before getting Vivitrol, compared to 6 percent who dropped out before a first dose of Suboxone.

Of those who actually started treatment, about half of both groups relapsed.

Methadone, a third treatment drug, was not part of the study.

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