Widely popular heartburn medications that block the secretion of acid into the stomach are associated with higher rates of chronic kidney disease, according to a new study by Johns Hopkins University researchers released last week.
The research raises more questions about commonly used drugs such as Nexium, Prilosec and Prevacid, which had long been considered effective with few side effects. In June, an unusual data-mining project by Stanford University researchers revealed evidence linking the medications to a greater risk of heart attacks. Previous analyses have linked the medications to bone fractures, gut infections and other health problems.
Neither the Stanford study nor the one published Jan. 11 could establish the drugs, known as “proton pump inhibitors,” as the cause of heart attacks or chronic kidney disease because they were conducted by reviewing the health records of large numbers of patients rather than by setting up a controlled experiment.
Nevertheless, the link to the onset of chronic kidney disease was clear enough that the study and an accompanying editorial recommended that patients, doctors and researchers delve into whether reducing intake of the drugs might cut the risk of kidney disease. Both papers were published in the journal JAMA Internal Medicine.
Chronic kidney disease can lead to kidney failure and the need for dialysis or a kidney transplant. More than 13 percent of people in the United States suffer from the disease, which also can lead to cardiovascular problems and greater than normal risk of death.
“As a nephrologist I’ve been worried about the medications for some time” because of evidence linking them to acute kidney problems, said Morgan Grams, an assistant professor of epidemiology at Hopkins’ Bloomberg School of Public Health. Grams and Benjamin Lazarus, an Australian physician, led the research team.
In a statement, Abigail Bozarth, a spokeswoman for AstraZeneca, which makes Nexium, said the company believes all its proton pump inhibitors “are generally safe and effective when used in accordance with the label. This has been established through human data studies and more than a decade of real world clinical use.” It said AstraZeneca was not consulted during the research.
Emails Friday to Novartis and Procter & Gamble, pharmaceutical companies that also make or distribute prescription and over-the-counter versions of the drugs, were not returned.
When they studied the records of more than 10,000 people treated in community-based settings, the researchers found a 20 percent to 50 percent greater risk of the onset of chronic kidney disease among users of the drugs than those who did not take them. The association also turned up when they examined the records of more than 248,000 people treated in a Pennsylvania hospital system.
The link to kidney disease did not appear when the researchers looked at medications such as Zantac and Pepcid, which combat heartburn in a different way, by blocking histamine production in the cells that line the stomach.
Users of the drugs tended to be more obese and to have other illnesses such as diabetes, but the link persisted when the researchers accounted for those problems.
