WASHINGTON — For thousands of newborns born in and around Boston; San Francisco; Kansas City, Missouri; and North Carolina over the next several years, a full genomic sequencing may be among the medical tests conducted in the first days of baby’s life.
The procedure is anything but routine. But $20 million in grants announced by the National Institutes of Health will help decide whether such genomic analysis should be among the routine screenings conducted on all newborns.
At issue in the studies to be undertaken are questions of health, efficiency, privacy and ethics, as well as more emotional issues of parent-child attachment. Will having information on a baby’s distant future health vulnerabilities make a difference in the kinds of medical treatments he or she gets, or on the ways his or her parents feed or care for him or her? When genomic analysis picks up on a genetic disorder or an inherited disease likely to crop up early, will even earlier interventions make a difference? Will physicians, parents and, ultimately, the children, understand the significance (or the lack thereof) of the information they now have?
Some of the concerns to be tested are more practical: Will a child get speedier and better treatment when adverse — or positive — reactions to certain drugs can be predicted? Can smaller genomic panels — those that sequence only the 2 percent of DNA made up of genes known to code for proteins in the body-offer the same wealth of usable information more cheaply?