Taylor Stephens had 22 points and Taylor Mills added 11 points and eight rebounds as La Center opened the season with a non-league win over a former Trico League rival.
The Wildcats and Chinooks played last season for the 1A district title. Kalama this season is playing as a Class 2B school.
Parker Esary scored 23 of her game-high 34 points in the second half as Kalama tried to rally from a 30-18 halftime deficit.
“Esary went crazy on us in the second half,” La Center coach Herm VanWeerdhuizen said. “A lot of her second half points came on 3-point plays as we tried to stop her by fouling and she still made baskets.”