ROCHESTER, Minn. — Transplanted livers change the profile of blood cells in the recipients, reducing the potential for organ rejection, Mayo Clinic research shows. The findings are published in Kidney International.
For decades, transplant experts have observed that liver transplant recipients often need less anti-rejection medication, known as immunosuppressive drugs, than recipients of other solid organs. Similarly, when patients receive a multiple-organ transplant that includes the liver along with any other organ, they need less immunosuppressive medication and have less incidence of rejection even if they are highly sensitive to cellular bad actors, known as antigens, from the donor organs.
The Mayo Clinic research explains why.
“This study shows that the liver transplant itself regulates the host’s immune responses. Compared to the other organs, the liver is immunologically a very active organ, so it is capable of regulating the immune responses against itself,” said lead author Dr. Timucin Taner, a transplant surgeon at Mayo Clinic.
When patients undergo a dual kidney-liver transplant, the liver has a protective effect on the kidney, the study found.