WASHINGTON – For the first time, scientists have used human cells to make structures that mimic the earliest stages of development, which they say will pave the way for more research without running afoul of restrictions on using real embryos.
Two papers published in the journal Nature detail how two teams of scientists independently made such structures.
They stressed that their work is only for research, not reproduction, but it likely will pose new ethical questions.
“Studying early human development is really difficult. It’s basically a black box,” said Jun Wu, a stem cell biologist at the University of Texas, Southwestern Medical Center.
“We believe our model can open up this field,” he said, if “you can test your hypothesis without using human embryos.”
Wu’s team used embryonic stem cells and the second team used reprogrammed skin cells to produce balls of cells that resemble one of the earliest stages of human development.
These balls, called blastocysts, form a few days after an egg has been fertilized but before the cells attach to the uterus to become an embryo. To differentiate their models from blastocysts created through fertilization, the researchers refer to the structures as “iBlastoids” and “human blastoids.”
“They shouldn’t be considered as equal to a blastocyst, although they are an excellent model for some aspects of biology,” said Jose Polo, an epigeneticist at Monash University in Australia who led the second research team.
Both groups stressed that the structures they made were not the same as naturally occurring embryos, and it’s unclear whether they could develop into viable embryos.
“The blastoids are less efficient in terms of generating structures mimicking later stage human embryos,” said Wu.
Scientists previously generated similar structures of mouse cells in a lab, but this is the first time they have been made from human cells. The new models correspond to about three to 10 days after fertilization, Wu said. Last year, researchers unveiled structures that model cells 18 to 21 days after fertilization.
Research involving human embryos and blastocysts is currently ineligible for federal funding in the U.S., and several states prohibit it outright.
Some scientists now use blastocysts donated from fertility clinics for research into the causes of infertility and congenital diseases. The new work should allow them to do such research at much larger scales, Polo said.
“This capacity to work at scale will revolutionize our understanding of these early stages of human development,” said Polo.
The scientists stressed that their creations were not intended to be used for human reproduction.
“There is no implantation,” said Amander Clark, a stem cell biologist at the University of California, Los Angeles who co-authored the paper with Polo.
