Hood to Coast (200 miles), Portland to Coast and Portland to Coast High School Challenge all kick off Friday. Teams will complete the relay event Saturday at Seaside, Ore.
This year’s event includes more than 20,400 runners and walkers and 4,200 volunteers.
In 2010, the event raised more than $500,000 for the American Cancer Society, the event’s charity partner.
Hood to Coast regularly fills up on opening day of registration in October, allowing 1,250 teams and turning away more than 1,000.
Runners and walkers can find 502 Honey Buckets along the course.
You can register to be a donor when obtaining your driver’s license or through the donor registry (http://www.donatelifenw.org).